Discover Knowledge at NMIMR

Search and explore the research, scholarly outputs, datasets, and scientific knowledge produced by the Noguchi Memorial Institute for Medical Research.

NMIMR Institutional Repository

The Institutional Repository of the Noguchi Memorial Institute for Medical Research provides a central platform for preserving, managing, and providing access to the Institute's research and scholarly outputs.

The repository supports the long-term preservation and dissemination of research produced at NMIMR and promotes greater visibility, accessibility, and reuse of scientific knowledge.

Research Communities

Explore research outputs by NMIMR department and research unit.

Bacterial Infections and Systems Biology

Research on bacterial pathogens, antimicrobial resistance, microbial genomics and systems biology.

Toxicology and Cancer Biology

Research on toxicology, environmental exposures, carcinogenesis and cancer biology.

Immunology and Vaccine Biology

Research on immune responses, host–pathogen interactions and vaccine development.

Viral and Emerging Infections

Research on viral pathogens, emerging infections, surveillance and outbreak preparedness.

Parasite and Vector Biology

Research on parasites, disease vectors, transmission dynamics and control.

Epidemiology and Implementation Sciences

Population health, surveillance, implementation research and health systems research.

Animal Models and Preclinical Sciences

Experimental models, translational research, preclinical studies and intervention evaluation.

Nutrition, Diets and Metabolic Sciences

Research on nutrition, dietary patterns, metabolism and diet-related diseases.

Cellular and Tissue Pathology

Research in histopathology, cytopathology, biomarkers and tissue-based diagnostics.

Recent Submissions

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    Dataset for: Programmatic implications of the efficiency of uptake of Onchocerca volvulus microfilariae by Simulium sp. vectors
    (Noguchi Memorial Institute for Medical Research, University of Ghana, 2026) Boakye, Daniel A.; Osei-Atweneboana, Mike Y.; Atta, Simon K.; Larbi, Irene A.; Mackenzie, Charles D.
    This dataset contains participant-level and vector microfilariae uptake data used in the study “Programmatic implications of the efficiency of uptake of Onchocerca volvulus microfilariae by Simulium sp. vectors.” The dataset includes skin microfilariae density measurements obtained from skin snip samples collected from the iliac crest and calf, together with measurements of vector microfilariae uptake. Data were collected at four study time points: baseline (Day 0), Day 8, Day 90, and Day 365 following ivermectin treatment. The dataset contains observations for 35 study participants and is provided in both wide and long formats. A data dictionary describing the variables and a file containing the geographical coordinates of the study communities are also included. The data support analyses assessing the relationship between human dermal Onchocerca volvulus microfilarial density and uptake of microfilariae by Simulium vectors, with implications for onchocerciasis transmission and elimination programmes.
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    Acute Febrile Illnesses
    (Noguchi Memorial Institute for Medical Research, University of Ghana) Dr. Charles Quaye
    The study aims to assess the accuracy of current malaria diagnostics and profile other febrile illnesses to improve case detection and management in health facilities in Ghana
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    Improving experiences and outcomes for individuals with severe stigmatizing skin diseases Developing an integrated case finding and management intervention in Ghana and Ethiopia. (SHARP Project)
    (Noguchi Memorial Institute for Medical Research, University of Ghana, 2022) Prof. Stephen Walker; Prof. Dorothy Yeboah-Manu; Prof. Richard Philips
    Severe stigmatising skin diseases (SSSDs) - including leprosy, yaws, Buruli ulcer (BU) and cutaneous leishmaniasis (CL) - are major causes of morbidity and are associated with disability, psychological distress and social isolation which can lead to stigmatisation, especially when treated late. As the different SSSDs share common characteristics, integration of programme activities may generate synergistic effects, especially when individuals living with SSSDs are engaged through the social structures most relevant to them. We plan to develop, implement and evaluate the feasibility, impact and cost-effectiveness of an integrated case finding and management SSSD intervention on outcomes for individuals living with SSSDs. We will work in Atwima Mponua District in Ghana, focussing on BU, yaws and leprosy and South Wollo in Ethiopia focussing on leprosy and CL. Atwima Mponua Municipal is one of the 260 Metropolitan, Municipal and District Assemblies (MMDAs) in Ghana, and forms part of the 43 MMDAs in the Ashanti Region, situated in the south-western part of the region. To inform the complex intervention design and strengthen implementation and evaluation, we propose formative work, outlined in this protocol. We will combine desk reviews, stakeholder workshops, surveys, ethnographic and qualitative research to understand the current context and organisational processes within the formal healthcare and local care systems from the provider, patient and community perspectives. We will explore with stakeholders’ strengths and challenges in areas including case-finding, management and stigma reduction for SSSDs, and the range of intervention possibilities and priorities for addressing these. Findings will inform interactive co-creation workshops with stakeholders to draft and refine the intervention package. Simultaneously, evaluation tools will be developed and validated. Subject to international and national COVID-19 guidelines, this research will take 9 months from September 2020
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    Rapid Sampling, Pooling and Targeted Deep Sequencing for Effective Malaria Molecular Surveillance
    (Noguchi Memorial Institute for Medical Research, University of Ghana, 2022) Prof Anita Ghansah
    The “Pooling Project” is an innovative malaria molecular surveillance (MMS) system which combines sampling, pooling and next generation sequencing to effectively monitor antimalarial resistance at a reduced cost. This project is a collaborative effort between the Noguchi memorial institute for medical research (NMIMR), the Ghana National malaria elimination program (NMEP) and supported by the Bailey lab-Brown University. The aim of the project is to ultimately provide near real-time access to actionable molecular surveillance data to improve the MMS system of Ghana. This is done through the rapid collection of blood samples from malaria patients by clinical staff as a preserved liquid sample followed by laboratory pooling, and next-generation sequencing. Ten NMEP sites are currently involved in this study and genotyping of samples is done in NMIMR with support from collaborators in Brown university, Bailey lab. Funding for this project is from the Bill and Melinda Gates foundation.
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    Strategies for the ENdgame: Targeting Infections among Non-compliants in the Elimination of Lymphatic filariasis (SENTINEL), SENTINEL PHASE I
    (Noguchi Memorial Institute for Medical Research, University of Ghana) Dziedzom K. de Souza
    Many lymphatic filariasis (LF) endemic countries, including Ghana, have successfully implemented mass drug administration (MDA) and made significant progress towards the elimination of the disease as a public health problem. Unfortunately, the existence of individuals who seldom or never take part in MDA pose a threat to this success, as they may serve as reservoirs of infection, re-infecting their communities. In this study we implemented strategies to identify and treat these individuals, while also assessing their level of infection, to inform programme actions. The study was undertaken in the Ahanta West hotspot district in Ghana, which has received more than 17 rounds of MDA. Through the community registers used in recording participation in MDAs, we identified and offered treatment to individuals who were ineligible or inadvertently missed the last MDA in April 2021 (Engage and Treat – E&T), or testing using the filariasis test strip followed by treatment to community members who for various reasons chose not to participate in the last MDA (Test and Treat – T&T). During the study, 23,879 individuals ranging from 5 to 98 years were reached, of whom 78% were not captured in the MDA register. Among the E&T group, 75.06% willingly received and swallowed the treatment drugs. The remaining 24.94% were offered testing followed by a reengagement to receive the drug in the T&T group. Overall, 22,830 (95.61%) of participants were treated by either strategy. Of the participants in the T&T group, 516 (8.66%; 95% CI= 7.96 – 9.41) were positive by the FTS. The highest antigen prevalence was detected among children 5 to 10 years, with 16.59% (95% CI= 12.02 – 22.06) and 22.54% (95% CI= 17.11 – 28.74) among females and males, respectively. Mapping of the data revealed that most infections are in a few select communities. Of the 516 FTS positives, 27.33% reportedly missed MDA once, 18.41% missed MDA twice and 54.26% missed all of the last three MDAs. The main reasons for missing MDA included absence (25.49%), travel (21.24%), being unaware of MDA (20.27%), refusals to take the drug (10.65%), illnesses (7.07%) and fear of adverse events (6.13%). This study demonstrates that greater sensitization and engagement strategies, with a test and treat strategy reserved for the most hesitant individuals, could significantly increase the number of individuals who receive treatment and therefore help districts reach their elimination targets by reducing the remaining reservoir or infection. NTD programmes require new tools to help them identify, engage and treat these individuals, as part of their overall monitoring and evaluation strategy.