Discover Knowledge at NMIMR

Search and explore the research, scholarly outputs, datasets, and scientific knowledge produced by the Noguchi Memorial Institute for Medical Research.

NMIMR Institutional Repository

The Institutional Repository of the Noguchi Memorial Institute for Medical Research provides a central platform for preserving, managing, and providing access to the Institute's research and scholarly outputs.

The repository supports the long-term preservation and dissemination of research produced at NMIMR and promotes greater visibility, accessibility, and reuse of scientific knowledge.

Research Communities

Explore research outputs by NMIMR department and research unit.

Bacterial Infections and Systems Biology

Research on bacterial pathogens, antimicrobial resistance, microbial genomics and systems biology.

Toxicology and Cancer Biology

Research on toxicology, environmental exposures, carcinogenesis and cancer biology.

Immunology and Vaccine Biology

Research on immune responses, host–pathogen interactions and vaccine development.

Viral and Emerging Infections

Research on viral pathogens, emerging infections, surveillance and outbreak preparedness.

Parasite and Vector Biology

Research on parasites, disease vectors, transmission dynamics and control.

Epidemiology and Implementation Sciences

Population health, surveillance, implementation research and health systems research.

Animal Models and Preclinical Sciences

Experimental models, translational research, preclinical studies and intervention evaluation.

Nutrition, Diets and Metabolic Sciences

Research on nutrition, dietary patterns, metabolism and diet-related diseases.

Cellular and Tissue Pathology

Research in histopathology, cytopathology, biomarkers and tissue-based diagnostics.

Recent Submissions

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    Translational studies of hookworm infection in Ghana, 2022
    (2022) Randi, Savanna; Owusu Donkor,Irene; Osabutey,Dickson; Gabriel Sumboh, Jeffrey; Appiah-Twum, Francis; Naa Lamitswei Lamptey,Amanda; Quaye, Isaac; Dorcoo,Christopher; bint Yusuf Ismail,Rahmat; Mensah Sedrzro,Kojo; Sandra Naa-Ami Josiah,Miranda; Horlortu,Prince; Plange,Doreen; Quartey,Joseph; Tetteh-Tsifoanya, Mark; Paraggio, Christina L.; Harrison, Lisa M.; Bungiro, Richard; Shabanova, Veronika; Humphries, Debbie; Wilson, Michael D; Cappello, Michael
    Hookworm infection is endemic in sub-Saharan Africa, including rural communities in Ghana. A cross-sectional study of hookworm infection was conducted in Beposo, Ghana (Bono East Region). We enrolled 1,047 participants, including men and women across the age spectrum (3-100 years). Following IRB review and subject consent, fecal and serum samples were collected, and household questionnaires were administered to capture demographic, socioeconomic, and water, sanitation, and hygiene practices within the community. Hookworm prevalence was 28.6% (285/996 individuals) as determined by Kato-Katz (KK) fecal microscopy. Of these, 92% (262/285) were classified as light intensity according to WHO standards. The highest prevalence was observed among children aged 11-16 years (33.5%, 52/155). Regular use of borehole water was associated with a higher incidence of hookworm compared to piped water (p<0.05). Screening fecal samples for hookworm DNA using qPCR yielded a cohort prevalence of 41% (404/992). Hookworm-infected subjects defined by either KK or qPCR exhibited higher levels of serum antibody (IgG) directed at Necator americanus soluble larval protein extracts (NaLEX) and adult worm excretory/secretory (NaES) proteins compared to those who were uninfected (p<0.001). The predictive utility of anti-NaES IgG levels was further demonstrated by Receiver Operating Characteristic curve analysis, which yielded an Area Under the Curve of 0.74 (p<0.0001) as a gauge of diagnostic validity. This study defines host demographic and behavioral factors associated with hookworm infection in Beposo and demonstrates the potential value of serologic testing as a tool for disease surveillance and monitoring the impact of control efforts in endemic communities.
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    Dataset for: Programmatic implications of the efficiency of uptake of Onchocerca volvulus microfilariae by Simulium sp. vectors
    (Noguchi Memorial Institute for Medical Research, University of Ghana, 2026) Boakye, Daniel A.; Osei-Atweneboana, Mike Y.; Atta, Simon K.; Larbi, Irene A.; Mackenzie, Charles D.
    This dataset contains participant-level and vector microfilariae uptake data used in the study “Programmatic implications of the efficiency of uptake of Onchocerca volvulus microfilariae by Simulium sp. vectors.” The dataset includes skin microfilariae density measurements obtained from skin snip samples collected from the iliac crest and calf, together with measurements of vector microfilariae uptake. Data were collected at four study time points: baseline (Day 0), Day 8, Day 90, and Day 365 following ivermectin treatment. The dataset contains observations for 35 study participants and is provided in both wide and long formats. A data dictionary describing the variables and a file containing the geographical coordinates of the study communities are also included. The data support analyses assessing the relationship between human dermal Onchocerca volvulus microfilarial density and uptake of microfilariae by Simulium vectors, with implications for onchocerciasis transmission and elimination programmes.
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    Acute Febrile Illnesses
    (Noguchi Memorial Institute for Medical Research, University of Ghana) Dr. Charles Quaye
    The study aims to assess the accuracy of current malaria diagnostics and profile other febrile illnesses to improve case detection and management in health facilities in Ghana
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    Improving experiences and outcomes for individuals with severe stigmatizing skin diseases Developing an integrated case finding and management intervention in Ghana and Ethiopia. (SHARP Project)
    (Noguchi Memorial Institute for Medical Research, University of Ghana, 2022) Prof. Stephen Walker; Prof. Dorothy Yeboah-Manu; Prof. Richard Philips
    Severe stigmatising skin diseases (SSSDs) - including leprosy, yaws, Buruli ulcer (BU) and cutaneous leishmaniasis (CL) - are major causes of morbidity and are associated with disability, psychological distress and social isolation which can lead to stigmatisation, especially when treated late. As the different SSSDs share common characteristics, integration of programme activities may generate synergistic effects, especially when individuals living with SSSDs are engaged through the social structures most relevant to them. We plan to develop, implement and evaluate the feasibility, impact and cost-effectiveness of an integrated case finding and management SSSD intervention on outcomes for individuals living with SSSDs. We will work in Atwima Mponua District in Ghana, focussing on BU, yaws and leprosy and South Wollo in Ethiopia focussing on leprosy and CL. Atwima Mponua Municipal is one of the 260 Metropolitan, Municipal and District Assemblies (MMDAs) in Ghana, and forms part of the 43 MMDAs in the Ashanti Region, situated in the south-western part of the region. To inform the complex intervention design and strengthen implementation and evaluation, we propose formative work, outlined in this protocol. We will combine desk reviews, stakeholder workshops, surveys, ethnographic and qualitative research to understand the current context and organisational processes within the formal healthcare and local care systems from the provider, patient and community perspectives. We will explore with stakeholders’ strengths and challenges in areas including case-finding, management and stigma reduction for SSSDs, and the range of intervention possibilities and priorities for addressing these. Findings will inform interactive co-creation workshops with stakeholders to draft and refine the intervention package. Simultaneously, evaluation tools will be developed and validated. Subject to international and national COVID-19 guidelines, this research will take 9 months from September 2020
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    Rapid Sampling, Pooling and Targeted Deep Sequencing for Effective Malaria Molecular Surveillance
    (Noguchi Memorial Institute for Medical Research, University of Ghana, 2022) Prof Anita Ghansah
    The “Pooling Project” is an innovative malaria molecular surveillance (MMS) system which combines sampling, pooling and next generation sequencing to effectively monitor antimalarial resistance at a reduced cost. This project is a collaborative effort between the Noguchi memorial institute for medical research (NMIMR), the Ghana National malaria elimination program (NMEP) and supported by the Bailey lab-Brown University. The aim of the project is to ultimately provide near real-time access to actionable molecular surveillance data to improve the MMS system of Ghana. This is done through the rapid collection of blood samples from malaria patients by clinical staff as a preserved liquid sample followed by laboratory pooling, and next-generation sequencing. Ten NMEP sites are currently involved in this study and genotyping of samples is done in NMIMR with support from collaborators in Brown university, Bailey lab. Funding for this project is from the Bill and Melinda Gates foundation.